Lactobacillus reuteri DSM17938 and its supernatant ameliorate parkinson's disease: insights from multi-omics and network pharmacology

The results of this article provide valuable insights by highlighting the crucial role of the gut-derived tryptophan metabolite xanthurenic acid in the neuroprotective effects of Lactobacillus reuteri DSM 17938 and its supernatant against Parkinson's disease. By integrating multi-omics, network pharmacology, molecular docking, and molecular dynamics simulations, we identified the AhR as a key target through which xanthurenic acid ameliorates PD.