NHLBI TOPMed: Genomic Summary Results for the Trans-Omics for Precision Medicine Program

The NHLBI Trans-Omics for Precision Medicine (TOPMed) program aims to identify the genetic basis of variation in biomedical phenotypes, with emphasis on those related to heart, lung, blood and sleep disorders, as part of a broader Precision Medicine Initiative. The TOPMed program has provided whole genome sequencing (WGS) to over 80 different studies that had previously recruited participants and collected extensive phenotype data. Many TOPMed investigators affiliated with these studies have organized their activities into phenotype-focused Working Groups and have developed genotype-phenotype association projects. These analyses have resulted in valuable cross-study Genomic Summary Results (GSR) that include whole genome association test results of both common and rare variants. Most of the analyses include data from multiple studies, some of which are based on sensitive populations, precluding public sharing of GSR. This dbGaP accession provides a mechanism for sharing sensitive GSR, using the controlled-access mechanisms of dbGaP to provide protections for sensitive populations.]]>
This analysis tested for gene-based aggregate rare variant association with batch-adjusted telomere length estimates generated directly from the whole-genome sequencing (WGS) data. Analysis was performed on a combined group of 109,122 individuals from 54 TOPMed studies. All samples with telomere length estimated from the WGS data from TOPMed Freeze 8 were considered for inclusion, provided they had consent that allowed for genetic analysis of telomere length. Only samples with sequencing read lengths of 151 or 152 base pairs and having age at blood draw data available were included. For the set of samples that were part of a duplicate pair/group (either part of the intended duplicates designed by TOPMed, or a duplicate identified across the studies through sample QC) only one sample from each duplicated pair/group was retained.
]]>This analysis tested for single variant association with batch-adjusted telomere length estimates generated directly from the whole-genome sequencing (WGS) data. Primary analysis was performed on a combined group of 109,122 individuals from 54 TOPMed studies. A secondary analysis was performed for all population groups with n > 5,000 (defined using HARE [harmonized ancestry and race/ethnicity], a newly developed machine learning approach for jointly leveraging reported race/ethnicity and genetic ancestry data in the definition of population strata for GWAS). The results included here are from samples assigned African ancestry (n=29,260) by HARE, from 38 TOPMed studies.All samples with telomere length estimated from the WGS data from TOPMed Freeze 8 were considered for inclusion, provided they had consent that allowed for genetic analysis of telomere length. Only samples with sequencing read lengths of 151 or 152 base pairs and having age at blood draw data available were included. For the set of samples that were part of a duplicate pair/group (either part of the intended duplicates designed by TOPMed, or a duplicate identified across the studies through sample QC) only one sample from each duplicated pair/group was retained.
]]>This analysis tested for single variant association with batch-adjusted telomere length estimates generated directly from the whole-genome sequencing (WGS) data. Primary analysis was performed on a combined group of 109,122 individuals from 54 TOPMed studies. A secondary analysis was performed for all population groups with n > 5,000 (defined using HARE [harmonized ancestry and race/ethnicity], a newly developed machine learning approach for jointly leveraging reported race/ethnicity and genetic ancestry data in the definition of population strata for GWAS). The results included here are from samples assigned Asian ancestry (n=5,683) by HARE, from 23 TOPMed studies.All samples with telomere length estimated from the WGS data from TOPMed Freeze 8 were considered for inclusion, provided they had consent that allowed for genetic analysis of telomere length. Only samples with sequencing read lengths of 151 or 152 base pairs and having age at blood draw data available were included. For the set of samples that were part of a duplicate pair/group (either part of the intended duplicates designed by TOPMed, or a duplicate identified across the studies through sample QC) only one sample from each duplicated pair/group was retained.
]]>This analysis tested for single variant association with batch-adjusted telomere length estimates generated directly from the whole-genome sequencing (WGS) data. Primary analysis was performed on a combined group of 109,122 individuals from 54 TOPMed studies. A secondary analysis was performed for all population groups with n > 5,000 (defined using HARE [harmonized ancestry and race/ethnicity], a newly developed machine learning approach for jointly leveraging reported race/ethnicity and genetic ancestry data in the definition of population strata for GWAS). The results included here are from samples assigned European ancestry (n=51,654) by HARE, from 43 TOPMed studies.All samples with telomere length estimated from the WGS data from TOPMed Freeze 8 were considered for inclusion, provided they had consent that allowed for genetic analysis of telomere length. Only samples with sequencing read lengths of 151 or 152 base pairs and having age at blood draw data available were included. For the set of samples that were part of a duplicate pair/group (either part of the intended duplicates designed by TOPMed, or a duplicate identified across the studies through sample QC) only one sample from each duplicated pair/group was retained.
]]>This analysis tested for single variant association with batch-adjusted telomere length estimates generated directly from the whole-genome sequencing (WGS) data. Primary analysis was performed on a combined group of 109,122 individuals from 54 TOPMed studies. A secondary analysis was performed for all population groups with n > 5,000 (defined using HARE [harmonized ancestry and race/ethnicity], a newly developed machine learning approach for jointly leveraging reported race/ethnicity and genetic ancestry data in the definition of population strata for GWAS). The results included here are from samples assigned Hispanic/Latino ancestry (n=18,019) by HARE, from 41 TOPMed studies.All samples with telomere length estimated from the WGS data from TOPMed Freeze 8 were considered for inclusion, provided they had consent that allowed for genetic analysis of telomere length. Only samples with sequencing read lengths of 151 or 152 base pairs and having age at blood draw data available were included. For the set of samples that were part of a duplicate pair/group (either part of the intended duplicates designed by TOPMed, or a duplicate identified across the studies through sample QC) only one sample from each duplicated pair/group was retained.
]]>80 different studies. This analysis tested for single variant association with batch-adjusted telomere length estimates generated directly from the whole-genome sequencing (WGS) data. Analysis was performed on a combined group of 109,122 individuals from 54 TOPMed studies. All samples with telomere length estimated from the WGS data from TOPMed Freeze 8 were considered for inclusion, provided they had consent that allowed for genetic analysis of telomere length. Only samples with sequencing read lengths of 151 or 152 base pairs and having age at blood draw data available were included. For the set of samples that were part of a duplicate pair/group (either part of the intended duplicates designed by TOPMed, or a duplicate identified across the studies through sample QC) only one sample from each duplicated pair/group was retained.A secondary analysis was performed for all population groups with n>5,000 (defined using HARE [harmonized ancestry and race/ethnicity], a newly developed machine learning approach for jointly leveraging reported race/ethnicity and genetic ancestry data in the definition of population strata for GWAS), which included European (n=51,654), African (n=29,260), Hispanic/Latino (n=18,019) and Asian (n=5,683) groups.
]]>The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for single variant association with hematocrit (HCT) in 13 TOPMed studies using freeze8 genotypes. Association between HCT and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with HCT values > 80% or < 5% were excluded. Participants from WHI with a HCT/HGB ratio >7 were also excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for single variant association with hemoglobin (HGB) in 13 TOPMed studies using freeze8 genotypes. Association between HGB and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with HGB values > 30 g/dL or < 5 g/dL were excluded. Participants from WHI with a HCT/HGB ratio >7 were also excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for single variant association with mean corpuscular hemoglobin (MCH) in 13 TOPMed studies using freeze8 genotypes. Association between MCH and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with >75 pg were excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for single variant association with mean corpuscular hemoglobin concentration (MCHC) in 13 TOPMed studies using freeze8 genotypes. Association between MCHC and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with ≥ 60 g/Dl were excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for single variant association with mean corpuscular volume (MCV) in 13 TOPMed studies using freeze8 genotypes. Association between MCV and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with value s>150 fL were excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for single variant association with red blood cell count (RBC) in 13 TOPMed studies using freeze8 genotypes. Association between RBC and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for single variant association with red blood cell width (RDW) in 13 TOPMed studies using freeze8 genotypes. Association between RDW and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from ≥80 different studies. This analysis tested for single variant association with basophil (BASO) in 13 TOPMed studies using freeze8 genotypes. Association between BASO and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with value ≥ 0.9 ul were exluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from ≥80 different studies. This analysis tested for single variant association with eosinophil (EOSIN) in 13 TOPMed studies using freeze8 genotypes.Association between EOSIN and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with value ≥ 20 ul were excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from ≥80 different studies. This analysis tested for single variant association with lymphocyte (LYMPHS) in 13 TOPMed studies using freeze8 genotypes.Association between LYMPHS and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with ≥ 150 ul were excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from ≥80 different studies. This analysis tested for single variant association with monocyte (MONOS) in 13 TOPMed studies using freeze8 genotypes. Associationbetween MONOS and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with ≥ 15 ul were excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from ≥80 different studies. This analysis tested for single variant association with neutrophil (NEUTRO) in 13 TOPMed studies using freeze8 genotypes.Association between NEUTRO and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with NEUTRO values ≥ 75 ul were excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from ≥80 different studies. This analysis tested for single variant association with white blood cell count (WBC) in 13 TOPMed studies using freeze8 genotypes.Association between WBC and all high quality variants with ≥ 5 copies of the minor allele was performed using a linear mixed model. Participants with WBC values ≥ 100 ul were exluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for gene-based rare variant aggregate aggregation with lymphocyte (LYMPHS) in 13 TOPMed studies using freeze8 genotypes. Association between LYMPHS and aggregation units with ≥ 5 copies of minor alleles across the unit were performed using a linear mixed model. Participants with > 150 µl were excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for gene-based rare variant aggregate aggregation with monocyte (MONOS) in 13 TOPMed studies using freeze8 genotypes. Association between MONOS and aggregation units with ≥ 5 copies of minor alleles across the unit were performed using a linear mixed model. Participants with > 15 µl were excluded.The TOPMed program is part of a broader Precision Medicine Initiative and provides whole-genome sequencing and other omics data with molecular, behavioral, imaging, environmental, and clinical data from ∼155k participants from >80 different studies. This analysis tested for gene-based rare variant aggregate aggregation with neutrophil (NEUTRO) in 13 TOPMed studies using freeze8 genotypes. Association between NEUTRO and aggregation units with ≥ 5 copies of minor alleles across the unit were performed using a linear mixed model. Participants with NEUTRO values > 75 µl were excluded.We performed a genome-wide gene-by-sex interaction analysis of atopy-related markers using whole-genome sequencing data based on 889 trios from the Genetic Epidemiology of Asthma in Costa Rica Study (GACRS) and 284 trios from the Childhood Asthma Management Program (CAMP).In brief, children in GACRS were aged 6 to 14 years and children in CAMP were aged 5 to 12 years old at enrollment who had asthma diagnosed by a physician. Both GACRS and CAMP used a family-based design focused on trios and similar protocols for phenotyping subjects.We performed a genome-wide assocation study (GWAS) in 3,931 individuals of passenger approximate clonal expansion rate (PACER), a statistical method that estimates the rate of clonal expansion in individuals that are carrying a single clonal hematopoiesis of indeterminate potential (CHIP) driver mutation. 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association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis and gene-based analysis using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Genome-wide association analysis of 1,135 metabolites in up to 16,359 participants using generalized linear mixed model.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Rare Variant Aggregate Test using STAAR.Genome-wide association analysis of HDLGenome-wide association analysis of LDLGenome-wide association analysis of TCGenome-wide association analysis of TGInclusion and exclusion criteria vary by TOPMed study and can be found in study-specific TOPMed accessions on dbGaP.]]>
The TOPMed program launched in 2014 with WGS in an initial set of 20 Phase 1 studies. Sequencing has expanded with approximately yearly Phases, totaling over 80 studies and 140,000 sequenced participants by 2020. TOPMed studies are sequenced across different centers to an average depth of 30X, with periodic joint calling and organization into discrete "data freezes" conducted by the TOPMed Informatics Research Center at the University of Michigan. Release of these WGS data freezes in study-specific accessions on dbGaP has been led by the TOPMed Data Coordinating Center (DCC) at the University of Washington, in collaboration with TOPMed study investigators and dbGaP curators. Following pilot studies, the Program began supporting generation of non-WGS omics data in TOPMed studies in Phase 4, including RNA-seq, methylomics, and metabolomics.]]>