GTSE1 binds TP53

Since MDM2-mediated ubiquitination of TP53 promotes translocation of TP53 to the cytosol, and since GTSE1-facilitated translocation of TP53 to the cytosol depends on the functional MDM2 (with no reported interaction between GTSE1 and MDM2) (Monte et al. 2004), it is plausible that GTSE1 binds to TP53 polyubiquitinated by MDM2. The interaction between TP53 and GTSE1 involves the C-terminal regulatory domain of TP53 and the C-terminus of GTSE1 (Monte et al. 2003).

鉴于MDM2介导的TP53泛素化促进了TP53向细胞质中的转移，且GTSE1促进的TP53向细胞质中的转移依赖于功能性的MDM2（尚无GTSE1与MDM2之间的相互作用报道）（Monte等，2004年），因此，GTSE1可能结合由MDM2泛素化的TP53。TP53与GTSE1的相互作用涉及TP53的C端调控域和GTSE1的C端（Monte等，2003年）。