Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties

This dataset supports our study “Systematic computational assessment of atrial function impairment due to fibrotic remodeling in electromechanical properties,” which explores the impact of electromechanical remodeling in the fibrotic left atrium. It contains deidentified, patient-specific left atrial geometries; complete parameter sets for baseline and fibrotic combinations; scripts used to perform the simulations; and the resulting output files.

Each geometry includes fibrosis patterns, fiber orientations, region tags, and pacing sites. Parameter files specify alterations in nine fibrosis-associated properties—conduction velocities, ion channel conductances, active tension scaling, myofilament kinetics, and tissue stiffness—across one-factor-at-a-time and fractional factorial sensitivity analysis setups. Simulation and preprocessing scripts are provided for reproducibility and can be executed using the Carpentry software framework (Numericor).

Output data, provided in CSV format, include left atrial pressure–volume (PV) loop recordings and hemodynamic variables from the coupled 3D electromechanical–0D circulatory model for all simulated conditions. These data quantify atrial work and contractile performance under varied remodeling scenarios.

The dataset is structured to enable replication of the published results and to support further investigations into the biophysical determinants of atrial dysfunction and stroke risk.