OCD Collaborative Genetic Association Study (OCGAS)

The OCD Collaborative Genetics Association Study Group (OCGAS) was funded by NIMH to conduct a genome-wide association study to identify disease susceptibility loci of early-onset obsessive-compulsive disorder (OCD). Collaborators at Johns Hopkins, Brown, Columbia, MGH, UCLA, and NIMH evaluated 2,000 individuals with OCD and collected DNA from these individuals and both their parents. The genotyping and analyses was performed in two stages. In the first stage 1,065 families (comprising 1406 patients with OCD and 2895 individuals in total) were genotyped on the Illumina OmniExpress GWA (SNPs) panel at the JHU SNP Center.]]>
The aim of the OCD Collaborative Genetics Association Study (OCGAS) was to identify common variants associated with OCD using an integrative analyses pipeline that involved association testing at both SNP and gene levels. A total of 1065 families were included in this study (comprising 1406 patients with OCD and 2895 individuals in total). Genotyping was performed at the Johns Hopkins SNP Center using Illumina’s HumanOmniExpress bead chips (Illumina, San Diego, CA, USA)Probands were required to meet DSM-IV criteria for OCD with onset of obsessions and/or compulsions before the age of 18 years. Subjects with brain disease, schizophrenia, severe mental retardation that does not permit an evaluation to characterize the psychiatric disorder, Tourette disorder (TS), or OCD occurring exclusively in the context of depression (secondary OCD) were excluded.]]>