The supplemental tables of "Minimal Invasive Removal of Leukotrichia followed by Hair Transplantation: A Novel Two-step Surgery in the Treatment of Stable Follicular Vitiligo".

This is the supplemental materials of "Minimal Invasive Removal of Leukotrichia followed by Hair Transplantation: A Novel Two-step Surgery in the Treatment of Stable Follicular Vitiligo". The word document introduced the materials and methods of the manuscripts. Table S1 showed the patients demographic and clinical characteristics. Table S2 indicated the patients' satisfaction with the cosmetic results after surgery.In the follow-up procedure, the vitiligo patches were assessed for the aspect of leukotrichia by the camera and the dermatoscope at 12 months after the transplantation (Medical Electronic Dermatoscope Imaging System, CH-DSIS-2000, Chuanghong Medical Technology Co., LTD, Guangzhou, China). Patient satisfaction was documented on a questionnaire based on the visual analogue scale (VAS) ranging from high dissatisfaction to high satisfaction with the outcome. Supplemental Figure 1. Follicular vitiligo. Overview of the two-step surgery treating with the patients with stable follicular vitiligo. Initially, hairs of the vitiligo lesion were shaved to 2–4 mm. After disinfecting and local anaesthetizing, an incision was made around or in the center of the vitiligo scalp with 11# scalpels. The length of the incision should not exceed half of the diameter of the lesion, and the depth of the incision should reach the subcutaneous layer. Both blunt and sharp separation of the subcutaneous tissue of the scalp was performed about 1cm exceed the range of leukotrichia, and the residual tissue attaching to the dermis was resected by the ophthalmic scissors. Then a 497 mm fenestrated cup curette was used to scrape back and forth against the undermined flap for the subcutaneous trimming until the white hairs were easily pulled out. After sufficient hemostasis and washing, the incision was sutured and bandaged with moderate pressure. The wound was rinsed by the Iodine-containing disinfectant three days after the surgery, and the suture was removed 7-9 days after operation. Hair transplantation through the FUE technique was performed into the vitiligo area when the incision healed 1-3 months later. Before disinfecting, hairs of the occipital donor site were shaved to a length of 1 mm. Anesthesia was finished in both the donor and recipient sites by tumescent fluid containing 0.2% lidocaine with 1:100,000 epinephrine. The hair grafts were obtained by using a 1-mm hollow punches. The grafts were picked by the micro-forceps and placed in iced Ringer’s solution. After being drilled by a 1.2-mm needle, the recipient sites were implanted grafts in the distribution accordingly to presupposed density of 35–45 FUs/cm2. The recipient sites were applied with the topical antibiotics for 2–3 days and the dressing were removed postoperatively on the third day. Supplemental Figure 2A. Removal of the whitening hair right after stage-one surgery. Supplemental Figure 2B. Hair follicle transplantation right after stage-two surgery.本内容为论文《微创拔除白发（leukotrichia）联合毛发移植：治疗稳定型毛囊性白癜风的新型两步手术》的补充材料。该Word文档介绍了该论文的材料与方法部分。表S1展示了受试者的人口统计学特征与临床特征，表S2呈现了受试者术后对手术美容效果的满意度。在术后12个月的随访中，采用相机与皮肤镜对白癜风皮损区的白发情况进行评估，所用设备为医用电子皮肤镜成像系统（CH-DSIS-2000，广州创弘医疗科技有限公司，中国）。受试者满意度采用基于视觉模拟评分法（VAS）的问卷进行记录，评分范围覆盖从极不满意到极满意的结局评价。补充图1：毛囊性白癜风，以及针对稳定型毛囊性白癜风患者的两步手术流程概览。手术第一步：先将白癜风皮损区的毛发剃至2~4mm长度。完成消毒与局部麻醉后，使用11号手术刀在白癜风头皮皮损周围或中心做切口，切口长度不得超过皮损直径的一半，切口深度需达皮下组织层。在超出白发范围约1cm的区域内，对头皮皮下组织进行钝性与锐性分离，再用眼科剪切除附着于真皮层的残留组织。随后使用497mm带孔杯状刮匙在潜行皮瓣上来回刮削以完成皮下修整，直至白发可轻松拔除。充分止血并冲洗创面后，缝合切口并施以适度压力包扎。术后第3天使用含碘消毒剂冲洗伤口，术后7~9天拆除缝线。待切口愈合1~3个月后，采用毛囊单位提取术（FUE）技术向白癜风皮损区实施毛发移植。毛发移植步骤：消毒前，将枕部供区毛发剃至1mm长度。供区与受区均使用含0.2%利多卡因及1:100000肾上腺素的肿胀麻醉液实施麻醉。使用1mm空心打孔器获取毛囊移植物，再用显微镊子夹持移植物并将其置于冰态林格液中。使用1.2mm针头在受区打孔后，按照预设密度35~45个毛囊单位/cm²将移植物植入对应位置。术后受区局部外用抗生素2~3天，术后第3天拆除敷料。补充图2A：一期手术后即刻拔除白发；补充图2B：二期手术后即刻实施毛囊移植。