Reductive Cross-Aldol Reaction Using Bromoaldehyde and an Aldehyde Mediated by Germanium(II): One-Pot, Large-Scale Protocol
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https://figshare.com/articles/dataset/Reductive_Cross_Aldol_Reaction_Using_Bromoaldehyde_and_an_Aldehyde_Mediated_by_Germanium_II_One_Pot_Large_Scale_Protocol/3289093
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资源简介：
The reaction of α-bromoaldehyde with aldehyde in the presence of GeCl2−dioxane gave the syn-selective cross-aldol equivalent. A catalytic
amount of Bu4NBr improved the yield and selectivity. The initially formed aldol adduct (β-germoxyaldehyde) did not suffer from over-reaction.
This system enabled an intramolecular aldol reaction to give cyclic compounds effectively. One-pot synthetic methodology including bromination
of aldehyde followed by cross-aldol reaction with the second aldehyde was successful on a large-scale.
创建时间：
2016-05-06
