Phase 1 Study of Ulixertinib (BVD 523) in Patients with Advanced Solid Malignancies

NIAID Data Ecosystem2026-03-14 收录

癌症靶向治疗

RNA-seq生物标志物

数据链接：

https://www.ncbi.nlm.nih.gov/sra/SRP398430 数据链接链接失效反馈

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资源简介：

RNAseq from tumor samples of patients treated on clinical trial Overall design: Pretreatment biopsies were obtained from responders and non-responders

创建时间：

2023-02-16

Chromatin and transcriptome remodeling under EGFR chemical inhibition in lung cancer. Chromatin and transcriptome remodeling under EGFR chemical inhibition in lung cancer

癌症靶向治疗

表观遗传调控

This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

NIAID Data Ecosystem200

Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system. Depletion of Nrf2 in pancreatic cancer cells shifts arginine metabolism into the phosphocreatine energy system

癌细胞重编程

癌症靶向治疗

Depletion of Nrf2 leads to an increase in cellular ROS, reduced glutathione and thiols, and profound reprogramming of metabolism. Unbiased transcriptome analyses show that key enzymes of glycolysis, p

NIAID Data Ecosystem60

Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462

蛋白质晶体

癌症靶向治疗

Crystal structure of PRMT5:MEP50 in complex with MTA and TNG462 Descriptor: 1,2-ETHANEDIOL, 5'-DEOXY-5'-METHYLTHIOADENOSINE, CHLORIDE ION, ... Authors: Whittington, D.A. Deposit date: 2025-01-31 Relea

Protein Data Bank Japan2025-03-19 更新30

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer

癌症靶向治疗

RAS信号通路抑制

Crystal structure of BRAF/MEK1 complex with NST-628 and an active RAF dimer Descriptor: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Dual specificity mitogen-activated protein kinase kina

Protein Data Bank Japan2024-07-10 更新60

Design and Optimization of Novel Benzimidazole- and Imidazo[4,5‑ b ]pyridine-Based ATM Kinase Inhibitors with Subnanomolar Activities

激酶抑制剂开发

癌症靶向治疗

The ATM kinase is a promising target in cancer treatment as an important regulator of the cellular response to DNA double-strand breaks. In this work, we present a new class of specific benzimidazole-

NIAID Data Ecosystem40

Phase 1 Study of Ulixertinib (BVD 523) in Patients with Advanced Solid Malignancies

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