Global expression profile of uterine cervical carcinoma in Indian patients.

Cervical cancer (CACX) is the tumor of the uterine cervix and its primary etiological factor is the infection of high risk human papilloma virus (hrHPV), primarily HPV16 and HPV18. CACX is the third most commonly diagnosed cancer and the fourth leading cause of cancer deaths in women worldwide. In India, CACX accounts for approximately 1,22,844 new cases and 67,477 deaths annually. It is evident that Indian women are getting diagnosed at invasive stages of CACX leading to poor prognosis. Here, we tried to understand the change in the expression profile during the development of the tumor starting from HPV-negative normal samples to invasive CACX samples and try to understand the pathogenesis of cervical carcinoma in Indian patients. Gene expression analysis was carried out on 11 invasive CACX samples and 5 HPV Negative Normal Controls. Moreover, cervical cancer cell lines with varying Human Papilloma virus (HPV) status namely, SiHa (HPV16 positive), Hela (HPV18 positive) and C33A (HPV negative) were also included.