Dataset of 335 novel T cell receptor (TR) alleles identified from 47 HPRC subjects

This dataset is based on high-quality genome assemblies provided by the Human Pangenome Reference Consortium (HPRC), which represent diverse human genomes to ensure comprehensive coverage of genetic diversity.

Using the gAIRR Suite (https://github.com/maojanlin/gAIRRsuite), we identified 335 novel T Cell Receptor (TR) alleles from 47 HPRC assemblies. These alleles are categorized into two groups:

TRV_novel.fastaContains novel T Cell Receptor Variable (TRV) alleles.

TRJ_novel.fastaContains novel T Cell Receptor Joining (TRJ) alleles.

Supporting Files:

TRV_novel_haplotype_seq.csvProvides a summary of TRV alleles identified in HPRC subjects, including novel alleles. Each row contains the nucleotide sequence of an allele and the corresponding haplotypes (h1 for paternal and h2 for maternal).

TRJ_novel_haplotype_seq.csvProvides a summary of TRJ alleles identified in HPRC subjects, including novel alleles. Each row contains the nucleotide sequence of an allele and the corresponding haplotypes (h1 for paternal and h2 for maternal)

The genome assemblies were sourced from the official HPRC GitHub repository:https://github.com/human-pangenomics/HPP_Year1_Assemblies.

This dataset offers a valuable resource for studying T Cell Receptor diversity and its role in immune function.