Epigenome analysis of intracranial mesenchymal tumors with FET-CREB fusions

Genome-wide DNA methylation profiling of 20 intracranial mesenchymal tumors with FET-CREB fusions encompassing both intracranial myxoid mesenchymal tumors and intracranial angiomatoid fibrous histiocytoma-like neoplasms. The Illumina Infinium EPIC 850k Human DNA Methylation Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpG sites of genomic DNA extracted from formalin-fixed, paraffin-embedded tumor tissue of 20 intracranial mesenchymal tumors with FET-CREB fusions. Bisulfite converted genomic DNA extracted from the 20 tumor samples was hybridized to Illumina Infinium EPIC 850k Human DNA Methylation Beadchip