Practical and Asymmetric Reductive Coupling of Isoquinolines Templated by Chiral Diborons
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https://figshare.com/articles/dataset/Practical_and_Asymmetric_Reductive_Coupling_of_Isoquinolines_Templated_by_Chiral_Diborons/5209018
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资源简介：
We herein describe
a chiral diboron-templated highly diastereoselective and enantioselective
reductive coupling of isoquinolines that provided expedited access
to a series of chiral substituted bisisoquinolines in good yields
and excellent ee’s under mild conditions. The method enjoys
a broad substrate scope and good functional group compatibility. Mechanistic
investigation suggests the reaction proceeds through a concerted [3,3]-sigmatropic
rearrangement.
创建时间：
2017-07-14
