China National GeneBank DataBase

The China National GeneBank database (CNGBdb) is a unified platform for biological big data sharing and application services. At present, CNGBdb has integrated a large amount of internal and external biological data from resources such as CNGB, NCBI, and the EBI. There are a number of sub databases in CNGBdb, including literature, variation, gene, genome, protein, sequence, organism, project, sample, experiment, run, and assembly. Based on underlying big data and cloud computing technologies, it provides various data services, including archive, analysis, knowledge search, management authorization of biological data. CNGBdb adopts data structures and standards of international omics, health, and medicine, such as The International Nucleotide Sequence Database Collaboration (INSDC), The Global Alliance for Genomics and Health GA4GH (GA4GH), Global Genome Biodiversity Network (GGBN), American College of Medical Genetics and Genomics (ACMG), and constructs standardized data and structures with wide compatibility. All public data and data services provided by CNGBdb are freely available to all users worldwide. CNGB Sequence Archive (CNSA) is the bionomics data repository of CNGBdb. CNGB Sequence Archive (CNSA) is a convenient and efficient archiving system of multi-omics data in life science, which provides archiving services for raw sequencing reads and further analyzed results. CNSA follows the international data standards for omics data, and supports online and batch submission of multiple data types such as Project, Sample, Experiment/Run, Assembly, Variation, Metabolism, Single cell, and Sequence. Moreover, CNSA has achieved the correlation of sample entities, sample information, and analyze data on some projects. Its data submission service can be used as a supplement to the literature publishing process to support early data sharing.

国家基因库数据库（China National GeneBank database，CNGBdb）是面向生物大数据共享与应用服务的统一平台。目前，CNGBdb已整合来自国家基因库（CNGB）、美国国家生物技术信息中心（NCBI）、欧洲生物信息研究所（EBI）等内外多源生物数据资源。该数据库下设多个子库，涵盖文献、变异、基因、基因组、蛋白质、序列、物种、项目、样本、实验、测序运行（run）与基因组组装（assembly）等类别。依托底层大数据与云计算技术，平台可提供生物数据归档、分析、知识检索、管理授权等多元化数据服务。CNGBdb采用国际组学、健康与医学领域的通用数据结构与标准，包括国际核苷酸序列数据库协作组织（The International Nucleotide Sequence Database Collaboration，INSDC）、全球基因组与健康联盟（Global Alliance for Genomics and Health，GA4GH）、全球基因组生物多样性网络（Global Genome Biodiversity Network，GGBN）以及美国医学遗传学与基因组学学会（American College of Medical Genetics and Genomics，ACMG），构建了兼容性优异的标准化数据体系与架构。平台面向全球用户免费开放全部公开数据与数据服务。CNGB序列归档系统（CNGB Sequence Archive，CNSA）为CNGBdb旗下的生物组学数据存储库。CNGB序列归档系统是一套便捷高效的生命科学多组学数据归档系统，可针对原始测序读长数据及后续分析结果提供归档服务。该系统遵循国际组学数据标准，支持项目、样本、实验/测序运行、基因组组装、变异、代谢组、单细胞及序列等多类数据的在线与批量提交。此外，CNSA已实现部分项目中样本实体、样本信息与分析数据的关联整合；其数据提交服务可作为学术论文出版流程的补充环节，助力实现早期数据共享。

搜集汇总

背景与挑战

背景概述

CNGBdb是一个统一的生物大数据共享与应用服务平台，整合了来自CNGB、NCBI和EBI等来源的内外部生物数据，涵盖文献、变异、基因等多个子数据库。该平台基于大数据和云计算技术，提供数据归档、分析和知识搜索等服务，并遵循国际组学与健康标准，所有公共数据和服务均免费向全球用户开放。其下属的CNGB序列归档系统（CNSA）作为生物组学数据存储库，支持多组学数据的便捷提交与管理。