Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with fragment-4 N10142 (SGC - Diamond I04-1 fragment screening)

Crystal structure of the second bromodomain of Pleckstrin homology domain interacting protein (PHIP) in complex with fragment-4 N10142 (SGC - Diamond I04-1 fragment screening) Descriptor: 1,2-ETHANEDIOL, 5-azanyl-2-(2-methylpropyl)-1,3-oxazole-4-carbonitrile, PH-interacting protein Authors: Krojer, T, Talon, R, Collins, P, Bradley, A, Cox, O, Amin, J, Szykowska, A, Burgess-Brown, N, Spencer, J, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F, Structural Genomics Consortium (SGC) Deposit date: 2015-11-09 Release date: 2016-04-27 Last modified: 2024-01-10 Method: X-RAY DIFFRACTION (1.37 Å) Cite: A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain. Chem Sci, 7, 2016

Pleckstrin同源结构域互作蛋白（Pleckstrin homology domain interacting protein, PHIP）第二个溴域（bromodomain）与片段-4 N10142（结构基因组学联盟-钻石I04-1片段筛选，SGC - Diamond I04-1 fragment screening）所形成复合物的晶体结构。组分信息：1,2-乙二醇、5-氨基-2-(2-甲基丙基)-1,3-恶唑-4-甲腈、PH互作蛋白。作者：Krojer, T、Talon, R、Collins, P、Bradley, A、Cox, O、Amin, J、Szykowska, A、Burgess-Brown, N、Spencer, J、Brennan, P、Bountra, C、Arrowsmith, C.H、Edwards, A、von Delft, F及结构基因组学联盟（Structural Genomics Consortium, SGC）。沉积日期：2015年11月9日；发布日期：2016年4月27日；最后修改日期：2024年1月10日。实验方法：X射线衍射法（X-RAY DIFFRACTION，分辨率1.37埃）。引用文献：《A poised fragment library enables rapid synthetic expansion yielding the first reported inhibitors of PHIP(2), an atypical bromodomain》，发表于《化学科学（Chemical Science）》，2016年，第7卷。