FOXM1-AKT positive regulation loop provides venetoclax resistance in AML

FOXM1 and AKT are crucial pro-oncogenic regulators of cancer therapy resistance. Due to reciprocal regulatory links they establish a positive feedback autoregulation loop in AML cells. Disruption of this loop via inhibition of either FOXM1 or AKT results in similar gene expression changes, drastic upregulation of HOXA genes and sensitization of AML cells to cytarabine and venetoclax treatment. For each experimental model and condition, two biological replicates were analyzed. Control samples were treated with viehicle alone (DMSO), with vehicle percentage not exceeding 0.3%.