Sensitivities (sens) and positive predictive values (ppv) for secondary structure models as a function of included information.

All values are given as percentages. Consensus structures were generated by RNAalifold [21] using SHAPE-directed sequence alignments (column pair 4). These structures were then used to constrain individual structure predictions (column pairs 5 and 6). Models were compared against three control predictions: individual predictions based on sequence alone (column 1), consensus predictions based on sequence-only alignment (column 2), and individual predictions made using only SHAPE reactivities and no sequence alignment information (column 3). Covariation structures are not available for C. difficile or H. volcanii 23S rRNAs.
Sensitivities (sens) and positive predictive values (ppv) for secondary structure models as a function of included information.