Genome Mining of a Prenylated and Immunosuppressive Polyketide from Pathogenic Fungi
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https://figshare.com/articles/dataset/Genome_Mining_of_a_Prenylated_and_Immunosuppressive_Polyketide_from_Pathogenic_Fungi/2442934
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资源简介：
Activation of the polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters in Aspergillus fumigatus and Neosartorya fischeri led to isolation of a new metabolite neosartoricin (3). The structure of 3 was solved by X-ray crystallography and NMR to be a prenylated anthracenone. 3 exhibits T-cell antiproliferative activity with an IC50 of 3 μM, suggestive of a physiological role as an immunosuppressive agent.
创建时间：
2016-02-19
