ChIP-Seq analysis C57BL/6 thymocytes
收藏NIAID Data Ecosystem2026-03-10 收录
下载链接：
https://www.ncbi.nlm.nih.gov/sra/SRP091748
下载链接
链接失效反馈官方服务：
资源简介：
In this study, we show that in addition to regulating DP thymocytes survival, RORgT also controls genes that regulate thymocyte migration, proliferation, and T cell receptor (TCR) selection. Strikingly, pharmacological inhibition of RORg skews TCR gene rearrangement, limits T cell repertoire diversity, and inhibits development of autoimmune encephalomyelitis. Thus, targeting RORgT not only inhibits Th17 cell development and function but also fundamentally alters thymic-emigrant recognition of self and foreign antigens. Overall design: Examination of RORgT-bound genomic sites in C57BL/6 mouse thymocytes.
创建时间：
2017-09-17
