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Proteome-wide ligandability maps of drugs with diverse cysteine-reactive chemotypes

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we identified the targets of clinical covalent drugs using an optimized analytical platform-QTRP (Quantitative Thiol Reactivity Profiling), and aim to identify new targets for illuminating uncharacterized covalent mechanisms of action and for the repurposing of an existing drug as a covalent recruiter for targeted protein degradation

创建时间:
2024-09-08
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