Expression profiles and their potential roles of tRNA-derived small RNAs in hippocampus of nicotine dependence rat

The mechanism of nicotine dependence and nicotine related pain remains unclear. tRNAs, a major source of small noncoding RNAs (ncRNA), are the immediate areas of research focus, which have an important role in many pathophysiological processes. However, the role of tRNAs on nicotine dependence and related pain hasn't been explored yet. In this study, our results indicated that the expression profiles of tRNAs have changed in nicotine treated rats as compared with normal rats, and among those, some differentially expressed tRNAs might be novel targets for nicotine dependence or nicotine related pain. Overall design: The expression profiles of tRNAs sequences were conducted using RNA extracted from the hippocampus of nicotine and saline treat rats.