Lactoferrin attenuated deoxynivalenol induced malfunction in mouse testis

DON impaired the male spermatogenesis and induced oxidative stress, testicular apoptosis and disruption of blood-testis barrier (BTB). The milk protein lactoferrin (LF) is an iron-binding glycogenprotein with multifunctions including anti-inflammation and antioxidant. The current study was aimed to investigate the beneficial effects of LF on spermatogenesis and integray of BTB of mice treated with diet DON. Overall design: Sexually mature male mice were fed diet inclusion of DON,and oral administration of LF for 35 days, a 2×2 factorial arrangement.