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N6-methyladenosine in Flaviviridae viral RNA genomes regulates infection

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NIAID Data Ecosystem2026-03-10 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP076674
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We use MeRIP-seq and PAR-CLIP in liver cell lines to detail the role of m6A in positive strand RNA virus infection. We find that hepatitis C virus, dengue virus, West Nile virus, yellow fever virus, and Zika virus all contain m6A within their genomes, with some conservation between viruses in methylation sites. Overall design: Study of m6A methylation in HCV, dengue, WNV, YFV, and Zika virus with two replicates using a polyA prep (m6A antibody, Synaptic Systems; 202 003). Identification of YTHDF1, YTHDF2, YTHDF3 binding sites on the HCV RNA genome using PAR-CLIP
创建时间:
2017-09-17
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