GOLGI ALPHA-MANNOSIDASE II in complex with (2R,3R,4R,5S)-1-(5-{[4-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)benzyl]oxy}pentyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol

GOLGI ALPHA-MANNOSIDASE II in complex with (2R,3R,4R,5S)-1-(5-{[4-(3,4-Dihydro-2H-1,5-benzodioxepin-7-yl)benzyl]oxy}pentyl)-2-(hydroxymethyl)-3,4,5-piperidinetriol Descriptor: (2~{R},3~{R},4~{R},5~{S})-1-[5-[[4-(3,4-dihydro-2~{H}-1,5-benzodioxepin-7-yl)phenyl]methoxy]pentyl]-2-(hydroxymethyl)piperidine-3,4,5-triol, Alpha-mannosidase 2, ZINC ION Authors: Armstrong, Z, Lahav, D, Johnson, R, Kuo, C.L, Beenakker, T.J.M, de Boer, C, Wong, C.S, van Rijssel, E.R, Debets, M, Geurink, P.P, Ovaa, H, van der Stelt, M, Codee, J.D.C, Aerts, J.M.F.G, Wu, L, Overkleeft, H.S, Davies, G.J. Deposit date: 2019-05-20 Release date: 2020-07-08 Last modified: 2024-11-13 Method: X-RAY DIFFRACTION (2.15 Å) Cite: Manno- epi -cyclophellitols Enable Activity-Based Protein Profiling of Human alpha-Mannosidases and Discovery of New Golgi Mannosidase II Inhibitors. J.Am.Chem.Soc., 142, 2020

与(2R,3R,4R,5S)-1-(5-{[4-(3,4-二氢-2H-1,5-苯并二氧杂环庚-7-基)苄基]氧基}戊基)-2-(羟甲基)-3,4,5-哌啶三醇结合的高尔基α-甘露糖苷酶II（Golgi Alpha-Mannosidase II）。配体描述为：(2R,3R,4R,5S)-1-[5-[[4-(3,4-二氢-2H-1,5-苯并二氧杂环庚-7-基)苯基]甲氧基]戊基]-2-(羟甲基)哌啶-3,4,5-三醇、α-甘露糖苷酶2及锌离子（ZINC ION）。作者包括Armstrong, Z.、Lahav, D.、Johnson, R.、Kuo, C.L.、Beenakker, T.J.M.、de Boer, C.、Wong, C.S.、van Rijssel, E.R.、Debets, M.、Geurink, P.P.、Ovaa, H.、van der Stelt, M.、Codee, J.D.C.、Aerts, J.M.F.G.、Wu, L.、Overkleeft, H.S.、Davies, G.J.。沉积日期：2019年5月20日；发布日期：2020年7月8日；最后修改日期：2024年11月13日。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.15埃）。引用文献：《Manno-表-环菲醇类物质实现人类α-甘露糖苷酶的活性导向蛋白质谱分析及新型高尔基甘露糖苷酶II抑制剂的发现》，《美国化学会志》（J. Am. Chem. Soc.），142卷，2020年。