CircNet

CircNet is a database for circular RNAs. In version 2, 2732 samples from 37 types of cancers were integrated into CircNet 2.0 and analyzed using several of the most reliable circRNA detection algorithms. Furthermore, target miRNAs were predicted from the full-length circRNA sequence using three reliable tools (PITA, miRanda and TargetScan). Additionally, 384 897 experimentally verified miRNA-target interactions from miRTarBase were integrated into CircNet.CircNet是一款面向环状RNA（circular RNA）的数据库。在2.0版本中，CircNet 2.0整合了来自37种癌症的2732个样本，并采用多款当前最可靠的环状RNA检测算法完成分析。进一步而言，研究人员借助PITA、miRanda与TargetScan三款可靠工具，从全长环状RNA序列中预测得到靶向微小RNA（microRNA）。除此以外，源自miRTarBase的384897条经实验验证的miRNA-靶标相互作用数据也被整合至CircNet数据库中。

搜集汇总

背景与挑战

背景概述

CircNet 2.0是一个专注于探索癌症中环状RNA调控网络的更新数据库，整合了37种癌症类型的2732个样本数据，并提供组织特异性表达谱及circRNA-miRNA-基因调控网络分析。该数据库采用多种可靠算法进行circRNA检测，并整合了实验验证的miRNA-靶点互作信息，支持功能富集分析。