Hypoxia promotes an inflammatory phenotype of fibroblasts in pancreatic cancer
收藏NIAID Data Ecosystem2026-03-14 收录
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https://www.ncbi.nlm.nih.gov/sra/SRP364816
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资源简介：
Pancreatic ductal adenocarcinoma (PDAC) is characterized by an extensive fibroinflammatory stromal reaction, which contributes to its hypovascular and hypoxic microenvironment. To assess the effects of hypoxia on fibroblast phenotype in an unbiased fashion, we performed RNA-sequencing profiling of mouse pancreatic stellate cells (PSCs) cocultured with mT3 PDAC cells exposed to normoxia (21% oxygen) or hypoxia (1% oxygen). Overall design: mRNA profiles of PSCs cultured in a transwell system with tumor organoids exposed to normoxia (21% oxygen) or hypoxia (1% oxygen) for 48 hours.
创建时间：
2022-09-28
