Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2

Cryo-EM structure of the human BRISC dimer complex bound to compound JMS-175-2 Descriptor: 1-[2,6-bis(chloranyl)phenyl]carbonyl-4-[[2,6-bis(chloranyl)phenyl]carbonylamino]-N-piperidin-4-yl-pyrazole-3-carboxamide, BRISC and BRCA1-A complex member 1, BRISC and BRCA1-A complex member 2, ... Authors: Chandler, F, Zeqiraj, E. Deposit date: 2023-07-24 Release date: 2025-02-05 Last modified: 2025-08-20 Method: ELECTRON MICROSCOPY (3.32 Å) Cite: Molecular glues that inhibit deubiquitylase activity and inflammatory signaling. Nat.Struct.Mol.Biol., 2025结合化合物JMS-175-2的人类BRISC二聚体复合物的冷冻电镜（Cryo-EM）结构 描述符：1-[2,6-二氯苯基]羰基-4-[[2,6-二氯苯基]羰基氨基]-N-哌啶-4-基-吡唑-3-甲酰胺、BRISC和BRCA1-A复合物成员1、BRISC和BRCA1-A复合物成员2…… 作者：Chandler F、Zeqiraj E 提交日期：2023-07-24 发布日期：2025-02-05 最后修改日期：2025-08-20 实验方法：电子显微镜（分辨率3.32 Å） 引用文献：《抑制去泛素化酶活性与炎症信号通路的分子胶》，《自然-结构与分子生物学》，2025年