Defective O-fucosylation of EDIL3 attenuates invasion and vascular remodeling of trophoblasts via LIFR signaling pathway in preeclampsia

Preeclampsia(PE)is a severe placental disorder that affects 3%-5% of all pregnancies worldwide. The primary cause of PE is abnormal placentationduring eanly pregnancy, including poor trophoblast invasion and insutficientapiral arteriole remodeling, Protein O-ucosylation is a type of protein posttranslational modification that is catalyzed by Protein O-fucosy'ltransferase(poFUT). However, the role and underlying mechanisms of protein O-fucosylation and poFUT1 in PE remain elusive.