Analysis of TC-mAb mice (Exp3: B1-B, B2-B)
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http://flowrepository.org/id/FR-FCM-Z5ZP
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The experiment had been performed to analyze B cell development of human antibody-procducing mice (TC-mAb mice). The flow cytometry experiment was designed to detect the subsets of Follicular B (B220hiCD19+CD93-CD21loCD23hi), marginal zone B (B220hiCD19+CD93-CD21hiCD23lo), and B1a B (B220loCD19+CD5+CD43+) in Spleen of 6, 8, and 20 week-old mice, and B1a B (CD19+CD5+CD23-), B1b B (CD19+CD5-CD23-), B2 B (CD19+CD5lo/-CD23+) in peritoneal exudate cells of 6, 8, and 20 week-old mice.
Notes:
This experiment corresponds to Figure 7d, e and Supplementary Figure 21-26 in the paper "Efficient human-like antibody repertoire and hybridoma production in trans-chromosomic mice carrying megabase-sized human immunoglobulin loci". Publication link: https://doi.org/10.21203/rs.3.rs-103241/v1
创建时间：
2022-03-01
