Magi2

Enables SMAD binding activity and type II activin receptor binding activity. Involved in several processes, including SMAD protein signal transduction; neuroligin clustering involved in postsynaptic membrane assembly; and positive regulation of synaptic vesicle clustering. Acts upstream of or within signal transduction. Located in several cellular components, including centriole; ciliary base; and photoreceptor inner segment. Is expressed in several structures, including branchial arch; genitourinary system; limb; nervous system; and vibrissa. Used to study schizophrenia. Human ortholog(s) of this gene implicated in nephrotic syndrome type 15. Orthologous to human MAGI2 (membrane associated guanylate kinase, WW and PDZ domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]

激活 SMAD 结合活性及 II 型活化素受体结合活性。参与多种生理过程，包括 SMAD 蛋白信号转导；参与突触后膜组装的神经节苷脂聚簇形成；以及突触囊泡聚簇的正调控。位于信号转导的上游或其中。存在于多个细胞组分中，如中心粒、纤毛基底部和光感受器内节。在多个结构中表达，包括鳃弓、泌尿生殖系统、肢体、神经系统及触须。用于研究精神分裂症。该基因的人类同源基因与 15 型肾病综合征有关。与人类 MAGI2（膜结合型鸟苷酸激酶，含有 WW 和 PDZ 结构域的 2）同源。[由基因组资源联盟提供，2024 年 11 月]