Data from: A genome-wide association study identifies a region strongly associated with symmetrical onychomadesis on chromosome 12 in dogs

Symmetrical onychomadesis causes periodic loss of claws in otherwise
healthy dogs. Genome-wide association analysis in 225 Gordon Setters
identified a single region associated with symmetrical onychomadesis on
chromosome 12 (spanning about 3.3 mb). A meta-analysis including also
English Setters indicated that this genomic region predisposes for
symmetrical onychomadesis in English Setters as well. The associated
region spans most of the major histocompatibility complex and nearly 1 Mb
downstream. Like many other autoimmune diseases, associations of
symmetrical onychomadesis with DLA class II alleles have been reported. In
this study, no associated markers were revealed within any of the
DLA-DRB1, -DQA1 or -DQB1 genes, and the odds for symmetrical onychomadesis
in the Gordon Setters were much higher, carrying significant single
nucleotide polymorphisms compared to the odds of any of the recorded
DLA-DRB1/DQA1/DQB1 haplotypes. We noticed that some of the associated DLA
haplotypes were different between the English Setters and the Gordon
Setters. Interestingly, associated SNP chip markers showed a more
consistent pattern of allelic variants related to cases or controls
regardless of breed. In conclusion, the associated genetic markers
identified in this study hold the potential to aid in selection of
breeding animals to reduce the frequency of symmetrical onychomadesis in
the dog.