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RNA-seq for gene expression changes upon silencing MEF2D-fusion in a MEF2D-HNRNPUL1 fusion-expressing Kasumi-7 cell line

ChEBI2020-06-30 更新2026-07-12 收录

白血病分子机制

基因融合功能研究

数据链接：

https://www.ebi.ac.uk/biostudies/ArrayExpress/studies/E-MTAB-8480 数据链接链接失效反馈

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RNA-seq for gene expression changes upon silencing MEF2D-fusion in a MEF2D-HNRNPUL1 fusion-expressing Kasumi-7 cell line

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创建时间：

2020-06-30

白血病分子机制

RNA-seq基因表达

TAF1 is essential for AE driven leukemogenesis. Depletion of TAF1 impairs the recruitment of AE to its target genes, interfering with its control of gene expression. The bromodomains of TAF1 associate

NIAID Data Ecosystem80

CD40 stimulation of chronic lymphocytic leukemia (CLL) cells. CD40 stimulation of chronic lymphocytic leukemia (CLL) cells

白血病分子机制

CD40

In this experiment we in vitro activated CLL cells on a layer of fibroblasts expressing CD40L (3T40) or nothing (3T3) for 48 hours. After the 48 hours, cells were taken off the fibroblasts and sorted

NIAID Data Ecosystem60

Additional file 2 of NSD2 E1099K drives relapse in pediatric acute lymphoblastic leukemia by disrupting 3D chromatin organization

白血病分子机制

染色质结构

Additional file 2. stable_genomic_loci.bed LOLA Analysis File of stable ATAC-seq peaks.

NIAID Data Ecosystem50

Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia [ChIP-Seq]. Chemical inhibition of ENL/AF9 YEATS domains in acute leukemia [ChIP-Seq]

白血病分子机制

YEATS结构域靶向治疗

Transcriptional co-regulators, which mediate chromatin-dependent transcriptional signaling, represent tractable targets to modulate tumorigenic gene expression programs with small molecules. Genetic l

NIAID Data Ecosystem60

Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T Cell Leukemogenesis. Direct Phosphorylation and Stabilization of MYC by Aurora B Kinase Promote T Cell Leukemogenesis

白血病分子机制

激酶-转录调控

The significance of MYC deregulation has been well-documented in T-cell acute lymphoblastic leukemia (T-ALL). MYC acts as an oncogenic driver in T-ALL and particularly in maintaining leukemia-initiati

NIAID Data Ecosystem50

RNA-seq for gene expression changes upon silencing MEF2D-fusion in a MEF2D-HNRNPUL1 fusion-expressing Kasumi-7 cell line

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