Competing risk models of treatment failure and treatment modification due to adverse event (n = 4662).

All models were adjusted for study site. Baseline CD4 cell count and adherence were not significant in univariate analysis for either outcome but are presented out of interest, as is the missing adherence category. Exposure category Other includes those exposed to blood products and unknown exposures. A (d4T/AZT/TDF)/NNRTI regimen comprises d4T/AZT/TDF + another NRTI + NNRTI. A PI-based regimen comprises dual NRTI + PI. Other regimen refers to all other ART. ¤Included in final treatment failure model; ◊Included in final modification due to adverse event model; ¥Adjusted for co-variables included in the final model; *Time updated; †p overall for linear trend; ‡p overall for heterogeneity; HR = hazard ratio; ART = antiretroviral therapy; IDU = intravenous drug use; HCV = hepatitis C virus; PI = protease inhibitor; NNRTI = non-nucleoside reverse transcriptase inhibitor; d4T = stavudine; AZT = zidovudine; TDF = tenofovir.Competing risk models of treatment failure and treatment modification due to adverse event (n = 4662).