Orally Bioavailable Quinoxaline Inhibitors of 15-Prostaglandin Dehydrogenase (15-PGDH) Promote Tissue Repair and Regeneration
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下载链接：
https://figshare.com/articles/dataset/Orally_Bioavailable_Quinoxaline_Inhibitors_of_15-Prostaglandin_Dehydrogenase_15-PGDH_Promote_Tissue_Repair_and_Regeneration/21482632
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资源简介：
15-Prostaglandin
dehydrogenase (15-PGDH) regulates the concentration
of prostaglandin E2 in vivo. Inhibitors of 15-PGDH
elevate PGE2 levels and promote tissue repair and regeneration. Here,
we describe a novel class of quinoxaline amides that show potent inhibition
of 15-PGDH, good oral bioavailability, and protective activity in
mouse models of ulcerative colitis and recovery from bone marrow transplantation.
创建时间：
2022-11-02
