Supplementary Material for: Metformin and Aging: A Review
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https://karger.figshare.com/articles/Supplementary_Material_for_Metformin_and_Aging_A_Review/9821528
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资源简介：
Metformin is sometimes proposed to be an “anti-aging” drug, based on preclinical experiments with lower-order organisms and numerous retrospective data on beneficial health outcomes for type 2 diabetics. Large prospective, placebo-controlled trials are planned, in pilot stage or running, to find a new use (or indication) for an aging population. As one of the metformin trials has “frailty” as its endpoint, similar to a trial with a plant-derived senolytic, the latter class of novel anti-aging drugs is briefly discussed. Concerns exist not only for vitamin B<sub>12</sub> and B<sub>6</sub> deficiencies, but also about whether there are adverse effects of metformin on individuals who try to remain healthy by maintaining cardiovascular fitness via exercise.
提供机构：
Karger Publishers
创建时间：
2019-09-13
