Loss of eIF4E in yeast results in induction of the integrated stress response in an eIF2a phosphorylation-independent manner
收藏Alliance of Genome Resources2026-08-01 收录
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To investigate translation events in the absence of eIF4E in Saccharomyces cerevisiae, we used a strain with a temperature-sensitive allele of eIF4E (cdc33-ts4-2). At 25°C, the factor is stable, but at 37°C it degrades. Here we conducted ribosome profiling and RNA-seq of both wild-type and temperature-sensitive strains subjected to 25°C and 37°C.
