Rap1 signalling

Rap1 (Ras-proximate-1) is a small G protein in the Ras superfamily. Like all G proteins, Rap1 is activated when bound GDP is exchanged for GTP. Rap1 is targeted to lipid membranes by the covalent attachment of lipid moieties to its carboxyl terminus. Movement of Rap1 from endosomal membranes to the plasma membrane upon activation has been reported in several cell types including Jurkat T cells and megakaryocytes. On activation, Rap1 undergoes conformational changes that facilitate recruitment of a variety of effectors, triggering it's participation in integrin signaling, ERK activation, and others.

Rap1（Ras-proximate-1）为Ras超家族中的一种小G蛋白。与所有G蛋白相似，当GDP被GTP取代时，Rap1被激活。通过脂质基团的共价结合至其羧基末端，Rap1被定位于脂质膜。在多种细胞类型中，包括Jurkat T细胞和巨核细胞，已报道了Rap1在激活后从内质膜向质膜的移动。在激活过程中，Rap1发生构象变化，有利于多种效应子的募集，触发其在整合素信号传导、ERK激活等过程中的参与。