High-resolution H&E images from the HistoSweep study across multiple tissues and diseases

This dataset contains eleven high-resolution hematoxylin and eosin (H&E) stained tissue images used in the study HistoSweep enables cellular-resolution tissue quality control for gigapixel images in digital pathology and spatial omics. The images have been pre-processed by scaling and padding to ensure consistency across samples and compatibility with digital pathology workflows. Contents Lung atypical adenomatous hyperplasia (AAH) and lung adenocarcinoma samples (contributed by H. Kadara laboratory): Lung_AAH.zip (1 H&E slide) Lung_AD.zip (3 H&E slides) Atherosclerosis (contributed by L. Maegdefessel laboratory): (1) Post Xenium profiling, (2) post CODEX profiling, (3) multi-sample tissue post CODEX profiling Artery_Atherosclerosis.zip (3 H&E slides) Lymph node from melanoma patient (contributed by A. Huang laboratory) LymphNode_Melanoma.zip (1 H&E slide) Kidney with renal cell carcinoma (RCC) (contributed by A. Huang laboratory) Kidney_RCC.zip (1 H&E slide) Kidney tissues processed with CosMx (contributed by K. Susztak laboratory): (1) One image containing two normal kidney samples, (2) One image containing a normal and a type 2 diabetes (T2D) kidney sample Kidney_MultiSample_T2D.zip (2 H&E slides) PurposeThese images provide a diverse set of gigapixel H&E slides spanning multiple tissue types and disease contexts. They serve as a resource for reproducing, validating, and extending the analyses performed with HistoSweep, as well as for general use in histopathology and spatial omics research.