Incidence of anaphylaxis or death in general population treated with benzathine penicillin: individual and pooled results, 1954–2012.

Notes:*16 patients had anaphylaxis after the first prescription of penicillin and 32 had anaphylaxis after the second prescription of penicillin. One patient had anaphylaxis in both prescriptions. Total patients that experienced anaphylaxis in this study = 47.‡There were reported 16 events of Jarisch-Herxheimer reaction, which were not considered adverse drug reaction in present review.