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Single-cell genomics reveals the peritoneal B1 cell development pathway and uncovers its BCR repertoire evolution in aging

Alliance of Genome Resources2026-08-01 收录

B1细胞发育

免疫衰老

数据链接：

http://www.informatics.jax.org/gxd/htexp_index/summary?arrayExpressID=E-MTAB-10061 数据链接链接失效反馈

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To understand B1 cell heterogeneity, we sequenced 8.1 weeks old and 64.4 weeks old mice.

应用场景：

免疫衰老

细胞因子反应

Whole blood cells from frail (n = 10) and non frail (n = 9) old individuals were stimulated with LPS+R848 during 24 h. IL-12/23p40, IL-12p70 and IL-23 were measured in cell-free supernatants by ELISA.

NIAID Data Ecosystem40

T cell responses to H1N1v and a longitudinal study of seasonal influenza vaccination - 2010

疫苗免疫机制

免疫衰老

Systems biology approach to examine effects of seasonal flu vaccination in adults of different ages on gene expression, cytokine stimulation and serum cytokines with parameters such as immune senescen

NIAID Data Ecosystem20

Expression data of young and aged mice derived CD8+ T cells stimulated in TCR or TRM condition for 3 days

免疫衰老

组织驻留记忆T细胞

Ageing can compromise antitumor immunity, but the underlying mechanism by which ageing causes CD8+ T cell dysfunction and thus limits their antitumor activity remains poorly understood. We found that

NIAID Data Ecosystem10

RNA-seq comparison of gene induction in RIG-I stimulated old and young human monocytes. Homo sapiens

免疫衰老

基因表达

Goal: The goal of this study was to compare gene induction in old and young human monocytes upon stimulation of these cells with a RIG-I specific ligand, based on previously published results which in

NIAID Data Ecosystem30

Data_Sheet_1_Defective Transcriptional Programming of Effector CD8 T Cells in Aged Mice Is Cell-Extrinsic and Can Be Corrected by Administration of IL-12 and IL-18.PDF

免疫衰老

T细胞功能调控

In response to infection with intracellular microorganisms, old mice mobilize decreased numbers of antigen-specific CD8 T cells with reduced expression of effector molecules and impaired cytolytic act

NIAID Data Ecosystem20

Single-cell genomics reveals the peritoneal B1 cell development pathway and uncovers its BCR repertoire evolution in aging

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