Effect of Antihypertensive Medication Intensity on Cardiovascular Events and Mortality in Older Adults with Hypertension.

Abbreviations: CV, cardiovascular; HF, heart failure.
aHazard ratios and 95% confidence intervals were estimated for moderate and high antihypertensive intensity group, in reference to the no anti-hypertensive group.
bThe outcome was occurrence during follow-up of acute coronary syndrome (MI, unstable angina, or cardiac revascularization), stroke, or hospitalization for heart failure. The variables included in the propensity score are noted in Table 1. For the full cohort analyses, the models included year of study entry, age, gender, race, prior myocardial infarction, prior stroke, prior hospitalization for heart failure, diabetes, atrial fibrillation, valvular heart disease, renal disease, statin use, current smoking status, difficulty walking, obesity, depression, cognitive impairment, number of non-antihypertensive medications, self-perceived health, blood pressure taken within past six month) and a continuous variable for propensity score. For the PS-matched cohort analyses, the models included the same 19 covariates with the propensity score matched sets as a clustering factor.
cThe outcome was death during follow-up among all cohort members. The model adjusted for the same covariates as for the cardiovascular event model.
dThe outcome was death among the subgroup of participants who experienced a CV event (coronary event, stroke, or hospitalization for heart failure) any time during follow-up. See Methods for analytical details. PS-matched analyses not performed due to small sample size.