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Crystal structure of the mutant K82A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP

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Protein Data Bank Japan2023-09-13 更新2026-03-21 收录
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Crystal structure of the mutant K82A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP Descriptor: 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase Authors: Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. Deposit date: 2011-04-20 Release date: 2012-04-25 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.49 Å) Cite: Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme. Biochemistry, 51, 2012

本数据集为嗜热自养甲烷杆菌(Methanobacterium thermoautotrophicum)来源的乳清苷5'-单磷酸脱羧酶(orotidine 5'-monophosphate decarboxylase)K82A突变体与抑制剂BMP结合的晶体结构,其中抑制剂BMP为6-羟基尿苷-5'-磷酸,复合物体系还包含甘油。 相关数据集详情如下: 作者:Fedorov, A.A.、Fedorov, E.V.、Desai, B.、Gerlt, J.A.、Almo, S.C. 提交日期:2011-04-20 发布日期:2012-04-25 最后更新日期:2023-09-13 实验方法:X射线衍射(分辨率1.49埃) 引用文献:《乳清苷5'-单磷酸脱羧酶的构象变化:基于晶体结构阐释5'-磷酸基团的酶激活机制》,《生物化学(Biochemistry)》,第51卷,2012年
创建时间:
2011-04-20
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