An aldehyde-containing intermediate of SufS in complex with (2R,3R)-3-ethoxycarbonylaziridine-2-carboxylic acid

An aldehyde-containing intermediate of SufS in complex with (2R,3R)-3-ethoxycarbonylaziridine-2-carboxylic acid Descriptor: (2~{S})-2-[(~{E})-[2-methyl-3-oxidanyl-5-(phosphonooxymethyl)pyridin-4-yl]methylideneamino]-3-oxidanylidene-propanoic acid, Cysteine desulfurase SufS, DI(HYDROXYETHYL)ETHER Authors: Nakamura, R, Fujishiro, T. Deposit date: 2024-10-11 Release date: 2025-07-16 Last modified: 2025-09-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Discovery of an Aziridine-Based Inhibitor That Targets Cysteine Desulfurase Type II SufS via High-Throughput X‐ray Crystallography. Acs Med.Chem.Lett., 16, 2025

本数据集为结合有(2R,3R)-3-乙氧羰基氮丙啶-2-羧酸的SufS含醛中间体。描述信息：(2S)-2-[(E)-[2-甲基-3-羟基-5-(膦酰氧基甲基)吡啶-4-基]亚甲基氨基]-3-氧代丙酸；涉及组分包括半胱氨酸脱硫酶SufS（Cysteine desulfurase SufS）以及二(羟乙基)醚。作者：中村，R、藤代，T。存入日期：2024-10-11；发布日期：2025-07-16；最后修改日期：2025-09-03。检测方法：X射线衍射（分辨率2.2 Å）。引用文献：《通过高通量X射线晶体学发现靶向II型半胱氨酸脱硫酶SufS的氮丙啶类抑制剂》，发表于《ACS医学化学通讯》，2025年，第16卷。