Rhea

Rhea is a comprehensive and non-redundant resource of expert-curated chemical and transport reactions of biological interest. Rhea can be used for enzyme annotation, genome-scale metabolic modeling and omics-related analysis. Rhea describes enzyme-catalyzed reactions covering the IUBMB Enzyme Nomenclature list as well as additional reactions, including spontaneously occurring reactions. Rhea is built on ChEBI (Chemical Entities of Biological Interest) ontology of small molecules to describe its reaction participants. Since December 2018, Rhea is the standard for enzyme annotation in UniProt.Rhea是一款经专家人工审校的、全面且无冗余的生物学相关化学反应与转运反应资源库。该资源库可用于酶注释、基因组规模代谢建模以及组学相关分析。Rhea收录的酶催化反应涵盖国际生物化学与分子生物学联合会（International Union of Biochemistry and Molecular Biology, IUBMB）酶命名清单中的内容，同时还包含额外反应，其中包括自发发生的反应。Rhea基于小分子的ChEBI（化学实体生物兴趣库，Chemical Entities of Biological Interest）本体来描述其反应参与物。自2018年12月起，Rhea成为UniProt（通用蛋白质资源，Universal Protein Resource）的酶注释标准。

搜集汇总

背景与挑战

背景概述

Rhea是一个由专家精心整理的生物相关化学反应数据库，涵盖酶催化和自发反应，可用于酶注释、代谢建模及组学分析。它基于ChEBI化学本体描述反应物，并自2018年起成为UniProt中酶注释的标准资源。