We report a pleiotropic disease due to loss-of-function mutations in RHBDF2, the gene encoding iRHOM2, in 2 kindreds with recurrent infections in different organs. One patient had recurrent pneumonia

NIAID Data Ecosystem70

Table_2_Gut Antibody Deficiency in a Mouse Model of CVID Results in Spontaneous Development of a Gluten-Sensitive Enteropathy.xlsx

免疫缺陷疾病

肠道微生物群-宿主互作

Primary immunodeficiencies are heritable disorders of immune function. CD19 is a B cell co-receptor important for B cell development, and CD19 deficiency is a known genetic risk factor for a rare form

NIAID Data Ecosystem20

Recruitment of Histone Deacetylase 3 to the Interferon-A Gene Promoters Attenuates Interferon Expression

先天免疫调控

干扰素基因表达

BackgroundInduction of Type I Interferon (IFN) genes constitutes an essential step leading to innate immune responses during virus infection. Sendai virus (SeV) infection of B lymphoid Namalwa cells t

NIAID Data Ecosystem80

Relative type III and type I IFN gene transcription in the brain and in the liver of infected C57BL/6 mice.

干扰素基因表达

免疫反应

aCalculations were as followed: for each mouse, the ratio between type III and type I IFN transcripts (IFN-λ/IFN-α or IFN-λ/IFN-β was calculated for the liver and for the brain. Mean ratios were then

Figshare2015-12-02 更新40

Interferon Signature in the Blood in Inflammatory Common Variable Immune Deficiency

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