Prediction of pathogenicity of the predicted amino acid change in BTPKD as determined by PolyPhen-2, Align GVGD and SIFT.

1Probably damaging, i.e., it is predicted to affect protein function or structure with a high degree of confidence.2Substitution classification in Align GVGD: GD> = 55+Tan(10)x(GV∧2.0) = >Class C55.3Number of aligned sequences at the position of the substitution.4SIFT scores range from 0 to 1. The amino acid substitution is predicted to be damaging if the score is 0.05.