Perturbational sequencing of patient tumors reveals midkine as an innate immune checkpoint in neuroendocrine tumors

MCC13 MDK-WT and MDK-KO tumor cells were treated with IFNb for 24 hours and underwent bulk RNAseq. There are in total 4 conditions (control + no stim, control + IFNb, MDK-KO + no stim, MDK-KO + IFNb) and each condition has 3 biological replicates (except for control + no stim condition, due to poor quality, it only has two biological replicates).