Fecal microbiota transplantation in irritable bowel syndrome patients

Imbalanced microbiota may contribute to the pathophysiology of irritable bowel syndrome, and fecal microbiota transplantation has been studied as a treatment option. We used both 16S rRNA gene amplicon and shotgun metagenomics data from a previous randomized, placebo controlled FMT trial on 49 IBS patients. The aim of this study was to analyze post-FMT changes in microbiota composition and functional potential.