Gene expression profiling of blood of Ebola virus disease survivors and Healthy donors by Next Generation Sequencing. Gene expression profiling of blood of Ebola virus disease survivors and Healthy donors by Next Generation Sequencing

Clinical follow-up of Ebola virus disease (EVD) survivors revealed a persistence of clinical symptoms and higher risk of mortality. Long-term analyses of the immune and inflammatory profiles of EVD survivors are currently lacking. Here, we evaluate gene expression profiles in 26 Guinean Ebola virus disease survivors (EBOV_S) and 33 Healthy donnors (HD). We show a persistent increase of several biomarkers of inflammation, immune activation and gut tissue damage in EBOV_S compared to healthy donors living in the same area. Gene expression profiling in blood revealed a significant enrichment in genes associated with antiviral responses in EBOV_S. Overall design: Analysis of whole-blood gene expression profiles of 26 Ebola virus disease survivors and 33 Healthy donnors