Metadata record for the manuscript: Characterization of evolution trajectory and immune profiling of brain metastasis in lung adenocarcinoma

<b>Summary</b>

This
metadata record provides details of the data supporting the claims of the
related manuscript: “Characterization of evolution
trajectory and immune profiling of brain metastasis in lung adenocarcinoma”.

The
related study aimed to characterise the evolutionary trajectory and immune
profiling of brain metastasis (BM), towards providing insights into the
development of novel therapeutic strategies.

Type of data:
whole exome sequencing, multiplex immunofluorescence

Subject of
data: samples from lung adenocarcinoma (LUAD) patients with BM and their paired
primary tumours

Sample size:
40 samples from 12 LUAD patients

Recruitment:
Patients with histologically or pathologically diagnosed lung cancer and
radiologically (CT and/or MRI) or pathologically confirmed brain metastasis
were recruited. Primary lung cancers, matched brain metastasis and peripheral
blood were collected.

<b><br></b><b>Data
access</b>

The whole
exome sequencing data are openly available in the <i>NCBI Sequence Read Archive</i> via the following accession: https://identifiers.org/ncbi/insdc.sra:SRP170084.
These data underlie Figures 2, 3 and 4 in the related article. Additionally,
the Supplementary Material file is available as part of this metadata record
as well as with the article itself. This Supplementary Material file contains
data associated with Figures 2, 3, 5 and 6 in the related article.

<b><br></b><b>Corresponding author(s) for this study</b>

Prof.
Caicun Zhou, M.D., Ph.D., Department of Medical Oncology, Shanghai Pulmonary
Hospital &amp; Thoracic Cancer Institute, Tongji University School of Medicine,
No. 507, Zheng Min Road, Shanghai, 200433, P.R. China. Tel: [phone];
Fax [phone]; E-mail: [e-mail].

Prof.
Jun Zhang, M.D., Ph.D., Division of Medical Oncology, Department of Internal Medicine;
Department of Cancer Biology, University of Kansas Cancer Center; University of
Kansas Medical Center, Kansas City, KS 66160, USA. Tel: [phone]; Fax
[phone]; E-mail: [e-mail].

Prof.
Jie Lin, M.D., Ph.D., Department of Oncology, The Second Affiliated Hospital of
Kunming Medical University, No. 377, Dianmian Road, Kunming, 650101, P.R.
China. Tel: [phone]; Fax [phone]; E-mail: [e-mail].

<br>
<b>Study approval </b>

The
study protocol was approved by the Institutional Review Board of Shanghai
Pulmonary Hospital, Tongji University School of Medicine (No. 2015-0709).
Written informed consent was obtained from all participants. The study was
conducted in accordance with the Declaration of Helsinki.