Role of RB1 in neurodegenerative diseases: Inhibition of post-mitotic neuronal apoptosis via Kmt5b

To better characterize the population of proliferating and apoptotic neuron in sibling and zrb1-ko, we performed 10× single-cell RNA sequencing (scRNA-seq) on whole-brain cells of sibling and zrbi-ko at 3 dpf. Overall design: Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enriched analysis of differentially expressed genes (DEGs) in NSPCs, myelencephalon neurons or cerebellum neurons between sibling and zrb1-ko mutants was performed.